Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global mapping of MtrA-binding sites links MtrA to regulation of its targets in Mycobacterium tuberculosis.

Microbiology (Reading, England) - 1 Jan 2018

Chatterjee Ayan, Sharma Arun Kumar, Mahatha Amar Chandra, Banerjee Srijon Kaushik, Kumar Manish, Saha Sudipto, Basu Joyoti, Kundu Manikuntala

Abstract excerpt

Mycobacterium tuberculosis employs two-component systems (TCSs) for survival within its host. The TCS MtrAB is conserved among mycobacteria. The response regulator MtrA is essential in M. tuberculosis. The genome-wide chromatin immunoprecipitation (ChIP) sequencing performed in this study suggested that MtrA binds upstream of at least 45 genes of M. tuberculosis, including those involved in cell wall remodelling,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP-Binding Cassette Transporters
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to Gene Expression Regulation, Bacterial

Share to Genome, Bacterial

Share to Macrophages

Share to Mycobacterium tuberculosis

Share to Nucleotide Motifs

Source

Identifiers

PMID: 29182512
DOI: 10.1099/mic.0.000585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global mapping of MtrA-binding sites links MtrA to regulation of its targets in Mycobacterium tuberculosis.PMID 29182512Read ↗

M. tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia.Semantic proximity Read ↗

MtrA regulation of essential peptidoglycan cleavage in <i>Mycobacterium tuberculosis</i> during infectionSemantic proximity Read ↗

Targeting multiple response regulators of Mycobacterium tuberculosis augments the host immune response to infection.Semantic proximity Read ↗

Novel MprA binding motifs in the phoP regulatory region in Mycobacterium tuberculosis.Semantic proximity Read ↗

Domains within RbpA Serve Specific Functional Roles That Regulate the Expression of Distinct Mycobacterial Gene SubsetsSemantic proximity Read ↗

The MprB Extracytoplasmic Domain Negatively Regulates Activation of the Mycobacterium tuberculosis MprAB Two-Component SystemSemantic proximity Read ↗

The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions.Semantic proximity Read ↗

Two-Component Regulatory Systems of MycobacteriaSemantic proximity Read ↗

Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosisSemantic proximity Read ↗

Regulatory role of Mycobacterium tuberculosis MtrA on dormancy/resuscitation revealed by a novel target gene-mining strategySemantic proximity Read ↗

The sensor kinase MtrB of Mycobacterium tuberculosis regulates hypoxic survival and establishment of infectionSemantic proximity Read ↗

Modulation of macrophage defense responses by Mycobacterial persistence protein MprA ( <i>Rv0981</i> ) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.