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Generation and Characterization of Induced Pluripotent Stem Cells Carrying An ASXL1 Mutation.

Stem cell reviews and reports - 1 Oct 2024

Wang Wenjun, Zhang Xiaoru, Li Yunan, Shen Jun, Li Yihan, Xing Wen, Bai Jie, Shi Jun, Zhou Yuan

Abstract excerpt

Additional sex combs-like 1 (ASXL1) is an epigenetic modulator frequently mutated in myeloid malignancies, generally associated with poor prognosis. Current models for ASXL1-mutated diseases are mainly based on the complete deletion of Asxl1 or overexpression of C-terminal truncations in mice models. However, these models cannot fully recapitulate the pathogenesis of myeloid malignancies. Patient-derived induced...

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PMID: 38884929
DOI: 10.1007/s12015-024-10737-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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