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Article

Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.

Journal of hematology & oncology - 21 Mar 2012

Gelsi-Boyer Véronique, Brecqueville Mandy, Devillier Raynier, Murati Anne, Mozziconacci Marie-Joelle, Birnbaum Daniel

Abstract excerpt

The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). They are generally associated with signs of...

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Source

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Identifiers

PMID: 22436456
DOI: 10.1186/1756-8722-5-12
PMCID: PMC3355025

Genes

ASXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.PMID 22436456Read ↗

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