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Article

Polymorphism of CYP3A4*18 is associated with anti-tuberculosis drug-induced hepatotoxicity.

Pharmacogenomics - 1 Jan 2024

Lee Shih-Wei, Chen Pei-Tzu, Liu Chi-Wei, Li Yuan-Hsu, Wu Lawrence Shih-Hsin

Abstract excerpt

Aim: The association between cytochrome P450 (CYP) gene polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ATDH) was investigated in patients with or without pre-existing liver diseases (PLD). Materials & methods: We followed 164 tuberculosis subjects, 58 with PLD and 106 without PLD. Polymorphisms in CYP2D6, CYP2C9, CYP2C19, CYP3A4 and CYP3A5 were analyzed using the TaqMan® SNP genotyping...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to CYP2C9 gene

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Share to Polymorphism, Single Nucleotide

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Source

Open in PubMed Open full text

Identifiers

PMID: 38884784
DOI: 10.1080/14622416.2024.2346069
PMCID: PMC11388135

Genes

CYP3A4
CYP2C19
CYP2C9
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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