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Article

CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study.

Journal of clinical pharmacy and therapeutics - 1 Oct 2012

Tang S-W, Lv X-Z, Zhang Y, Wu S-S, Yang Z-R, Xia Y-Y, Tu D-H, Deng P-Y, Ma Y, Chen D-F, Zhan S-Y

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: The pathogenic mechanism of antituberculosis drug-induced hepatotoxicity (ATDH) is thought to involve drug-metabolizing enzymes including N-acetyl transferase2 (NAT2), cytochrome P4502E1 (CYP2E1) and glutathione S-transferase (GST) M1, T1. The associations between genetic polymorphisms of those genes and ATDH have been reported but with inconsistent results. Moreover, most studies...

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Share to Antitubercular Agents
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Cytochrome P450 Family 2

Share to Glutathione Transferase

Share to Inactivation, Metabolic

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Source

Identifiers

PMID: 22335459
DOI: 10.1111/j.1365-2710.2012.01334.x

Genes

GSTM1
GSTT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study.PMID 22335459Read ↗

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