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Article

Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2015

Fernandes Débora Christina Ricardo Oliveira, Santos Ney Pereira Carneiro, Moraes Milene Raiol, Braga Ana Cristina Oliveira, Silva Cleonardo Augusto, Ribeiro-dos-Santos Andrea, Santos Sidney

Abstract excerpt

OBJECTIVES: The treatment of tuberculosis (TB) remains a challenge owing to the high incidence of drug-induced hepatotoxicity. The aim of this study was to examine the effect of two gene polymorphisms, one in the CYP2B6 (rs3745274) gene and one in the CYP3A5 (rs776746) gene, on the development of hepatotoxicity in patients treated with anti-TB drugs in a Brazilian Amazon population. METHODS: TB patients who were...

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Source

Identifiers

PMID: 25271170
DOI: 10.1016/j.ijid.2014.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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