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Article

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases - 1 Jan 2000

Santos Eliana Abreu, Gonçalves José Carlos Saraiva, Fleury Marcos K, Kritski Afrânio L, Oliveira Martha M, Velasque Luciane S, E Silva José Roberto Lapa, Estrela Rita de Cássia E

Abstract excerpt

SETTING: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH). DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and GSTT1 deletion polymorphisms have been associated with adverse events caused by INH. OBJECTIVE: To characterize the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31697922
DOI: 10.1016/j.bjid.2019.09.003
PMCID: PMC9428211

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