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Genome-wide association and replication study of anti-tuberculosis drugs-induced liver toxicity

26 Sept 2016

Abstract excerpt

Drug-induced liver injury (DILI) is a well-recognized adverse event of anti tuberculosis drugs (ATD) possibly associated with genetic variations. The objective of this study was to perform genome-wide association study (GWAS) to identify genetic variants associated with the risk for ATD induced liver toxicity in Ethiopian patients. Treatment-naïve newly diagnosed tuberculosis patients ( n = 646) were enrolled...

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PMID: 27671213
DOI: 10.1186/s12864-016-3078-3

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