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Article

A microdeletion event at 19q13.43 in IDH-mutant astrocytomas is strongly correlated with MYC overexpression.

Acta neuropathologica communications - 14 Jun 2024

Ülgen Ege, Gerlevik Umut, Gerlevik Sıla, Oktay Yavuz, Sezerman Osman Uğur, Turcan Şevin, Ozduman Koray

Abstract excerpt

MYC dysregulation is pivotal in the onset and progression of IDH-mutant gliomas, mostly driven by copy-number alterations, regulatory element alterations, or epigenetic changes. Our pilot analysis uncovered instances of relative MYC overexpression without alterations in the proximal MYC network (PMN), prompting a deeper investigation into potential novel oncogenic mechanisms. Analysing comprehensive genomics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38877600
DOI: 10.1186/s40478-024-01811-1
PMCID: PMC11177509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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