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Article

MYCN amplification defines an aggressive phenotype in IDH-mutant gliomas.

The journal of pathology. Clinical research - 1 Sept 2025

Xie Xujun, Yan Qin, Wang Fang, Lu Jiabin, Zhang Yuandong, Xi Shaoyan

Abstract excerpt

In alignment with the latest WHO classification system, which underscores the integration of molecular alterations in glioma diagnosis and grading, this study investigates the prognostic significance of MYCN amplification in IDH-mutant gliomas, a relationship that remains poorly characterized despite its established association with adverse outcomes in various malignancies. A cohort of 190 patients with...

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Source

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Identifiers

PMID: 40857163
DOI: 10.1002/2056-4538.70045
PMCID: PMC12380010

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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