Article
Novel CIC point mutations and an exon-spanning, homozygous deletion identified in oligodendroglial tumors by a comprehensive genomic approach including transcriptome sequencing.
PloS one - 1 Jan 2013
Eisenreich Sophie, Abou-El-Ardat Khalil, Szafranski Karol, Campos Valenzuela Jaime A, Rump Andreas, Nigro Janice M, Bjerkvig Rolf, Gerlach Eva-Maria, Hackmann Karl, Schröck Evelin, Krex Dietmar, Kaderali Lars, Schackert Gabriele, Platzer Matthias, Klink Barbara
Abstract excerpt
Oligodendroglial tumors form a distinct subgroup of gliomas, characterized by a better response to treatment and prolonged overall survival. Most oligodendrogliomas and also some oligoastrocytomas are characterized by a unique and typical unbalanced translocation, der(1,19), resulting in a 1p/19q co-deletion. Candidate tumor suppressor genes targeted by these losses, CIC on 19q13.2 and FUBP1 on 1p31.1, were only...
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