IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.

doi:10.1038/srep27569

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Article

IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation.

Scientific reports - 10 Jun 2016

Oktay Yavuz, Ülgen Ege, Can Özge, Akyerli Cemaliye B, Yüksel Şirin, Erdemgil Yiğit, Durası I Melis, Henegariu Octavian Ioan, Nanni E Paolo, Selevsek Nathalie, Grossmann Jonas, Erson-Omay E Zeynep, Bai Hanwen, Gupta Manu, Lee William, Turcan Şevin, Özpınar Aysel, Huse Jason T, Sav M Aydın, Flanagan Adrienne, Günel Murat, Sezerman O Uğur, Yakıcıer M Cengiz, Pamir M Necmettin, Özduman Koray

Abstract excerpt

The single nucleotide polymorphism rs55705857, located in a non-coding but evolutionarily conserved region at 8q24.21, is strongly associated with IDH-mutant glioma development and was suggested to be a causal variant. However, the molecular mechanism underlying this association has remained unknown. With a case control study in 285 gliomas, 316 healthy controls, 380 systemic cancers, 31 other CNS-tumors, and 120...

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PMID: 27282637
DOI: 10.1038/srep27569
PMCID: PMC4901315

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