Article
Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers.
The Journal of pathology - 1 Jan 2012
Yip Stephen, Butterfield Yaron S, Morozova Olena, Chittaranjan Suganthi, Blough Michael D, An Jianghong, Birol Inanc, Chesnelong Charles, Chiu Readman, Chuah Eric, Corbett Richard, Docking Rod, Firme Marlo, Hirst Martin, Jackman Shaun, Karsan Aly, Li Haiyan, Louis David N, Maslova Alexandra, Moore Richard, Moradian Annie, Mungall Karen L, Perizzolo Marco, Qian Jenny, Roldan Gloria, Smith Eric E, Tamura-Wells Jessica, Thiessen Nina, Varhol Richard, Weiss Samuel, Wu Wei, Young Sean, Zhao Yongjun, Mungall Andrew J, Jones Steven J M, Morin Gregg B, Chan Jennifer A, Cairncross J Gregory, Marra Marco A
Abstract excerpt
Oligodendroglioma is characterized by unique clinical, pathological, and genetic features. Recurrent losses of chromosomes 1p and 19q are strongly associated with this brain cancer but knowledge of the identity and function of the genes affected by these alterations is limited. We performed exome sequencing on a discovery set of 16 oligodendrogliomas with 1p/19q co-deletion to identify new molecular features at...
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