Article
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.
Blood - 15 Oct 2006
Mercher Thomas, Wernig Gerlinde, Moore Sandra A, Levine Ross L, Gu Ting-Lei, Fröhling Stefan, Cullen Dana, Polakiewicz Roberto D, Bernard Olivier A, Boggon Titus J, Lee Benjamin H, Gilliland D Gary
Abstract excerpt
Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia associated with a poor prognosis. However, there are relatively few insights into the genetic etiology of AMKL. We developed a screening assay for mutations that cause AMKL, based on the hypothesis that constitutive activation of STAT5 would be a biochemical indicator of mutation in an upstream effector tyrosine kinase. We screened...
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