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Longitudinal quantitative assessment of TMEV-IDD-induced MS phenotypes in two inbred mouse strains using automated video tracking technology.

Experimental neurology - 1 Sept 2024

Djabirska Iskra, Delaval Laetitia, Tromme Audrey, Blomet Joël, Desmecht Daniel, Van Laere Anne-Sophie

Abstract excerpt

Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system affecting over 2.5 million people worldwide. Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a murine model that reproduces the progressive form of MS and serves as a reference model for studying virus-induced demyelination. Certain mouse strains such as SJL are highly susceptible to this...

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PMID: 38876197
DOI: 10.1016/j.expneurol.2024.114851

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