Article
Optimal methods to characterize the G93A mouse model of ALS.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases - 1 Mar 2005
Miana-Mena Francisco J, Muñoz Maria J, Yagüe Gema, Mendez Mario, Moreno Maria, Ciriza Jesús, Zaragoza Pilar, Osta Rosario
Abstract excerpt
In the present study, we used the SOD1 (G93A) mutant transgenic mice as a model of amyotrophic lateral sclerosis (ALS). This model is widely used as a laboratory tool to study experimental treatments in vivo for ALS to investigate new therapeutic strategies for this neurodegenerative disease. Such studies require the objective quantification of different parameters while mice develop the disease. We have applied...
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