Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease.

PloS one - 1 Jan 2020

Heikkinen Taneli, Bragge Timo, Bhattarai Niina, Parkkari Teija, Puoliväli Jukka, Kontkanen Outi, Sweeney Patrick, Park Larry C, Munoz-Sanjuan Ignacio

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by severe disruption of cognitive and motor functions, including changes in posture and gait. A number of HD mouse models have been engineered that display behavioral and neuropathological features of the disease, but gait alterations in these models are poorly characterized. Sensitive high-throughput tests of fine motor function...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Mice, Transgenic

Share to Motor Activity

Share to Posture

Source

Open in PubMed Open full text

Identifiers

PMID: 33370315
DOI: 10.1371/journal.pone.0243052
PMCID: PMC7769440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease.PMID 33370315Read ↗

High-speed video gait analysis reveals early and characteristic locomotor phenotypes in mouse models of neurodegenerative movement disorders.Semantic proximity Read ↗

Force-plate quantification of progressive behavioral deficits in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing.Semantic proximity Read ↗

The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseasesSemantic proximity Read ↗

Sub-second analysis of locomotor activity in Parkinsonian miceSemantic proximity Read ↗

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.Semantic proximity Read ↗

Different Purkinje cell pathologies cause specific patterns of progressive ataxia in miceSemantic proximity Read ↗

Longitudinal analysis of the behavioural phenotype in R6/1 (C57BL/6J) Huntington's disease transgenic mice.Semantic proximity Read ↗

Gait as a Quantitative Translational Outcome Measure in Angelman SyndromeSemantic proximity Read ↗

Temporal Phenotypic Changes in Huntington's Disease Models for Preclinical Studies.Semantic proximity Read ↗

A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.