Gait as a Quantitative Translational Outcome Measure in Angelman Syndrome

Abstract excerpt

Angelman Syndrome (AS) is a genetic neurodevelopmental disorder characterized by developmental delay, lack of speech, seizures, intellectual disability, and walking and balance disorders. Recently, motor ability became an interesting outcome measure in AS, as it is broad including ataxia, hypotonia, delayed and abnormal walking and postural movements and affects nearly every individual with AS. We predict that gai...

Topics

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• Biomechanical Phenomena
• Disease Models, Animal
• Huntingtin Protein
• Huntington Disease
• Mice
• Mice, Transgenic
• Motor Activity
• Posture

Identifiers and source

Literature Corpus work

7e38df8a-6609-57e8-a04c-92b8e09b4c90

DOI

10.1101/2021.08.13.456146