Article
Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2007
Lad Heena V, Liu Lin, Payá-Cano José L, Fernandes Cathy, Schalkwyk Leonard C
Abstract excerpt
Immobility in the tail suspension test (TST) is considered a model of despair in a stressful situation, and acute treatment with antidepressants reduces immobility. Inbred strains of mouse exhibit widely differing baseline levels of immobility in the TST and several quantitative trait loci (QTLs) have been nominated. The labor of manual scoring and various scoring criteria make obtaining robust data and...
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