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Article

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

1 Apr 2019

Abstract excerpt

The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations with body mass index (BMI) and obesity-related cardiometabolic diseases. We found that the maximal efficacy of β-arrestin recruitment to MC4R, rather than canonical Gα s -mediated cyclic...

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PMID: 31002796
DOI: 10.1016/j.cell.2019.03.044

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