The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.

doi:10.2337/db24-0192

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Article

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.

Diabetes - 1 Sept 2024

Zeini Maya, Laurenti Marcello C, Egan Aoife M, Muthusamy Kalpana, Ramar Anisha, Vella Emma, Bailey Kent R, Cobelli Claudio, Dalla Man Chiara, Vella Adrian

Abstract excerpt

The T allele at rs7903146 in TCF7L2 increases the rate of conversion from prediabetes to type 2 diabetes. This has been associated with impaired β-cell function and with defective suppression of α-cell secretion by glucose. However, the temporal relationship of these abnormalities is uncertain. To study the longitudinal changes in islet function, we recruited 128 subjects, with 67 homozygous for the...

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Identifiers

PMID: 38869455
DOI: 10.2337/db24-0192
PMCID: PMC11333375

Genes

TCF7L2

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