Article
TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).
Diabetes care - 1 Mar 2018
Srinivasan Shylaja, Kaur Varinderpal, Chamarthi Bindu, Littleton Katherine R, Chen Ling, Manning Alisa K, Merino Jordi, Thomas Melissa K, Hudson Margo, Goldfine Allison, Florez Jose C
Abstract excerpt
OBJECTIVE: The rs7903146 T allele in transcription factor 7 like 2 (TCF7L2) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear. We evaluated the physiologic and hormonal effects of TCF7L2 genotype before and after interventions that influence glucose physiology. RESEARCH DESIGN AND METHODS: We genotyped rs7903146 in 608 individuals without diabetes and recorded...
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