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Article

A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth.

Diabetes care - 1 Oct 2020

Galderisi Alfonso, Tricò Domenico, Pierpont Bridget, Shabanova Veronika, Samuels Stephanie, Dalla Man Chiara, Galuppo Brittany, Santoro Nicola, Caprio Sonia

Abstract excerpt

OBJECTIVE: The risk genotype for the common variant rs7903146 of the transcription factor 7-like-2 (TCF7L2) gene has been found to affect the incretin response in healthy and obese adults; however, whether a similar functional defect is also present in obese adolescents remains unexplored. Herein, we examined the functional effect of the rs7903146 variant in the TCF7L2 gene on the incretin effect and determined...

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Source

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Identifiers

PMID: 32788279
DOI: 10.2337/dc20-0445
PMCID: PMC7510033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth.PMID 32788279Read ↗

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