TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes.

doi:10.2337/db15-1233

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Article

TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes.

Diabetes - 1 Feb 2016

Shah Meera, Varghese Ron T, Miles John M, Piccinini Francesca, Dalla Man Chiara, Cobelli Claudio, Bailey Kent R, Rizza Robert A, Vella Adrian

Abstract excerpt

The diabetes-associated allele in TCF7L2 increases the rate of conversion to diabetes; however, the mechanism by which this occurs remains elusive. We hypothesized that the diabetes-associated allele in this locus (rs7903146) impairs insulin secretion and that this defect would be exacerbated by acute free fatty acid (FFA)-induced insulin resistance. We studied 120 individuals of whom one-half were homozygous for...

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Identifiers

PMID: 26525881
DOI: 10.2337/db15-1233
PMCID: PMC4747457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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