Article
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
PloS one - 1 Jan 2016
van der Kroef Sabrina, Noordam Raymond, Deelen Joris, Akintola Abimbola A, Jansen Steffy W M, Postmus Iris, Wijsman Carolien A, Beekman Marian, Mooijaart Simon P, Slagboom P Eline, van Heemst Diana
Abstract excerpt
BACKGROUND: The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver glucose production, and an increased risk of type 2 diabetes. Nevertheless, the impact of rs7903146 on daily glucose trajectories remains unclear. Continuous glucose monitoring (CGM) can estimate glycemia and glycemic variability based on consecutive...
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