Article
Data-Driven Phenotyping of Presymptomatic Type 1 Diabetes Using Longitudinal Autoantibody Profiles.
Diabetes care - 1 Aug 2024
Ghalwash Mohamed, Anand Vibha, Ng Kenney, Dunne Jessica L, Lou Olivia, Lundgren Markus, Hagopian William A, Rewers Marian, Ziegler Anette-G, Veijola Riitta
Abstract excerpt
OBJECTIVE: To characterize distinct islet autoantibody profiles preceding stage 3 type 1 diabetes. RESEARCH DESIGN AND METHODS: The T1DI (Type 1 Diabetes Intelligence) study combined data from 1,845 genetically susceptible prospectively observed children who were positive for at least one islet autoantibody: insulin autoantibody (IAA), GAD antibody (GADA), or islet antigen 2 antibody (IA-2A). Using a novel...
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