Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.

Diabetologia - 1 Jul 2013

Achenbach P, Hummel M, Thümer L, Boerschmann H, Höfelmann D, Ziegler A G

Abstract excerpt

AIMS/HYPOTHESIS: Islet autoantibody-positive children progress to type 1 diabetes at variable rates. In our study, we asked whether characteristic autoantibody and/or gene profiles could be defined for phenotypes showing extreme progression. METHODS: Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interferon-Induced Helicase, IFIH1
Share to Interleukin-2 Receptor alpha Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lectins, C-Type

Share to Monosaccharide Transport Proteins

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Receptor, ErbB-3

Share to Zinc Transporter 8

Source

Identifiers

PMID: 23539116
DOI: 10.1007/s00125-013-2896-y

Genes

IFIH1
INS
PTPN22
CTLA4
ERBB3
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.PMID 23539116Read ↗

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.Semantic proximity Read ↗

Predictors of slow progression to diabetes in children with multiple islet autoantibodies.Semantic proximity Read ↗

A strategy to find gene combinations that identify children who progress rapidly to type 1 diabetes after islet autoantibody seroconversion.Semantic proximity Read ↗

Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years.Semantic proximity Read ↗

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 DiabetesSemantic proximity Read ↗

Data-Driven Phenotyping of Presymptomatic Type 1 Diabetes Using Longitudinal Autoantibody Profiles.Semantic proximity Read ↗

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.Semantic proximity Read ↗

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.Semantic proximity Read ↗

Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.Semantic proximity Read ↗

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.Semantic proximity Read ↗

Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study.Semantic proximity Read ↗

The longitudinal loss of islet autoantibody responses from diagnosis of type 1 diabetes occurs progressively over follow-up and is determined by low autoantibody titres, early-onset, and genetic variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.