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Article

Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.

Diabetologia - 1 Jul 2013

Achenbach P, Hummel M, Thümer L, Boerschmann H, Höfelmann D, Ziegler A G

Abstract excerpt

AIMS/HYPOTHESIS: Islet autoantibody-positive children progress to type 1 diabetes at variable rates. In our study, we asked whether characteristic autoantibody and/or gene profiles could be defined for phenotypes showing extreme progression. METHODS: Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping...

Topics

Adaptor Proteins, Signal Transducing
Adolescent
Autoantibodies
CTLA-4 Antigen
Cation Transport Proteins
Child
Child, Preschool
DEAD-box RNA Helicases
Diabetes Mellitus, Type 1
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

HLA-DQ Antigens

Humans

Infant

Infant, Newborn

Insulin

Interferon-Induced Helicase, IFIH1

Source

Identifiers

PMID: 23539116
DOI: 10.1007/s00125-013-2896-y

Genes

IFIH1
INS
PTPN22
CTLA4
ERBB3
PTPN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children.PMID 23539116Read ↗

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