Article
Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.
Diabetes care - 1 Sept 2020
Vehik Kendra, Bonifacio Ezio, Lernmark Åke, Yu Liping, Williams Alistair, Schatz Desmond, Rewers Marian, She Jin-Xiong, Toppari Jorma, Hagopian William, Akolkar Beena, Ziegler Anette G, Krischer Jeffrey P
Abstract excerpt
OBJECTIVE: The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The Environmental Determinants of Diabetes in the Young (TEDDY) study. RESEARCH DESIGN AND METHODS: Eligible children with increased HLA-DR-DQ genetic risk for T1D were...
Topics
- Adolescent
- Autoantibodies
- Child
- Child, Preschool
- Diabetes Mellitus, Type 1
- Disease Progression
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Glutamate Decarboxylase
- HLA-DQ Antigens
- HLA-DR Antigens