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Article

Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study.

Diabetes care - 1 Sept 2020

Vehik Kendra, Bonifacio Ezio, Lernmark Åke, Yu Liping, Williams Alistair, Schatz Desmond, Rewers Marian, She Jin-Xiong, Toppari Jorma, Hagopian William, Akolkar Beena, Ziegler Anette G, Krischer Jeffrey P

Abstract excerpt

OBJECTIVE: The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the risk of autoantibody spreading to the second-appearing autoantibody and further progression to clinical disease in The Environmental Determinants of Diabetes in the Young (TEDDY) study. RESEARCH DESIGN AND METHODS: Eligible children with increased HLA-DR-DQ genetic risk for T1D were...

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Source

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Identifiers

PMID: 32641373
DOI: 10.2337/dc19-2547
PMCID: PMC7440899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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