Article
Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories.
Nature communications - 21 Mar 2022
Kwon Bum Chul, Anand Vibha, Achenbach Peter, Dunne Jessica L, Hagopian William, Hu Jianying, Koski Eileen, Lernmark Åke, Lundgren Markus, Ng Kenney, Toppari Jorma, Veijola Riitta, Frohnert Brigitte I
Abstract excerpt
Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to predict. Here we show, by longitudinal sampling of islet autoantibodies (IAb) to insulin, glutamic acid decarboxylase and islet antigen-2 that disease progression follows distinct trajectories. Of...
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