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Hippocampal transcriptome-wide association study and pathway analysis of mitochondrial solute carriers in Alzheimer's disease.

Translational psychiatry - 10 Jun 2024

Tian Jing, Jia Kun, Wang Tienju, Guo Lan, Xuan Zhenyu, Michaelis Elias K, Swerdlow Russell H, Du Heng

Abstract excerpt

The etiopathogenesis of late-onset Alzheimer's disease (AD) is increasingly recognized as the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and genetic risks. Although the role of mitochondrial dysfunction in the pathogenesis of AD has been well-appreciated, the interaction between mitochondrial function and genetic variability in promoting dementia is still poorly...

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Identifiers

PMID: 38858380
DOI: 10.1038/s41398-024-02958-0
PMCID: PMC11164935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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