Association of APOE genotype and cerebrospinal fluid Aβ and tau biomarkers with cognitive and motor phenotype in amyotrophic lateral sclerosis.

doi:10.1111/ene.16374

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Article

Association of APOE genotype and cerebrospinal fluid Aβ and tau biomarkers with cognitive and motor phenotype in amyotrophic lateral sclerosis.

European journal of neurology - 1 Sept 2024

Maranzano Alessio, Verde Federico, Dubini Antonella, Torre Silvia, Colombo Eleonora, Doretti Alberto, Gentile Francesco, Manini Arianna, Milone Ilaria, Brusati Alberto, Peverelli Silvia, Santangelo Serena, Spinelli Edoardo Gioele, Torresani Erminio, Gentilini Davide, Messina Stefano, Morelli Claudia, Poletti Barbara, Agosta Federica, Ratti Antonia, Filippi Massimo, Silani Vincenzo, Ticozzi Nicola

Abstract excerpt

OBJECTIVE: Little is known about amyotrophic lateral sclerosis (ALS)-nonspecific cognitive deficits - most notably memory disturbance - and their biological underpinnings. We investigated the associations of the Alzheimer's disease (AD) genetic risk factor APOE and cerebrospinal fluid (CSF) biomarkers Aβ and tau proteins with cognitive and motor phenotype in ALS. METHODS: APOE haplotype was determined in 281 ALS...

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PMID: 38853763
DOI: 10.1111/ene.16374
PMCID: PMC11295165

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APOE

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Source receipt: pubmed, retrieved 7 Sept 2026.

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