Article
β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies.
Neurology - 15 Dec 2020
Ferreira Daniel, Przybelski Scott A, Lesnick Timothy G, Lemstra Afina W, Londos Elisabet, Blanc Frederic, Nedelska Zuzana, Schwarz Christopher G, Graff-Radford Jonathan, Senjem Matthew L, Fields Julie A, Knopman David S, Savica Rodolfo, Ferman Tanis J, Graff-Radford Neill R, Lowe Val J, Jack Clifford R, Petersen Ronald C, Mollenhauer Brit, Garcia-Ptacek Sara, Abdelnour Carla, Hort Jakub, Bonanni Laura, Oppedal Ketil, Kramberger Milica G, Boeve Bradley F, Aarsland Dag, Westman Eric, Kantarci Kejal
Abstract excerpt
OBJECTIVE: In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by APOE genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype. METHODS: We included 417 patients with DLB (age 45-93 years, 31% women). Positivity on β-amyloid (A+) and tau (T+)...
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