Article
The fork remodeler helicase-like transcription factor in cancer development: all at once.
Biochimica et biophysica acta. Molecular basis of disease - 1 Oct 2024
Waheed Yossma, Mojumdar Aditya, Shafiq Mohammad, de Marco Ario, De March Matteo
Abstract excerpt
The Helicase-like Transcription Factor (HLTF) is a member of the SNF2-family of fork remodelers, primarily studied for its capacity to provide DNA Damage Tolerance (DDT) and to induce replication fork reversal (RFR). HLTF is recruited at stalled forks where both its ATPase motor and HIP116 Rad5p N-terminal (HIRAN) domains are necessary for regulating its interaction with DNA. HIRAN bestows specificity to ssDNA...
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