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Article

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.

Proceedings of the National Academy of Sciences of the United States of America - 11 Mar 2008

Unk Ildiko, Hajdú Ildikó, Fátyol Károly, Hurwitz Jerard, Yoon Jung-Hoon, Prakash Louise, Prakash Satya, Haracska Lajos

Abstract excerpt

Human helicase-like transcription factor (HLTF) is frequently inactivated in colorectal and gastric cancers. Here, we show that HLTF is a functional homologue of yeast Rad5 that promotes error-free replication through DNA lesions. HLTF and Rad5 share the same unique structural features, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18316726
DOI: 10.1073/pnas.0800563105
PMCID: PMC2268824

Genes

HLTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18316726-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.PMID 18316726Read ↗

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