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Article

Biologically-informed killer cell immunoglobulin-like receptor gene annotation tool.

Bioinformatics (Oxford, England) - 1 Nov 2024

Ford Michael K B, Hari Ananth, Zhou Qinghui, Numanagić Ibrahim, Sahinalp S Cenk

Abstract excerpt

SUMMARY: Natural killer (NK) cells are essential components of the innate immune system, with their activity significantly regulated by Killer cell Immunoglobulin-like Receptors (KIRs). The diversity and structural complexity of KIR genes present significant challenges for accurate genotyping, essential for understanding NK cell functions and their implications in health and disease. Traditional genotyping...

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Identifiers

PMID: 39432666
DOI: 10.1093/bioinformatics/btae622
PMCID: PMC11549020

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