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Article

Pan-cancer analysis of CDKN2A alterations identifies a subset of gastric cancer with a cold tumor immune microenvironment.

Human genomics - 31 May 2024

Deng Chao, Li Zi-Xi, Xie Chen-Jun, Zhang Qing-Lin, Hu Ben-Shun, Wang Mei-Dan, Mei Jie, Yang Chen, Zhong Zhangfeng, Wang Ke-Wei

Abstract excerpt

BACKGROUND: Although CDKN2A alteration has been explored as a favorable factor for tumorigenesis in pan-cancers, the association between CDKN2A point mutation (MUT) and intragenic deletion (DEL) and response to immune checkpoint inhibitors (ICIs) is still disputed. This study aims to determine the associations of CDKN2A MUT and DEL with overall survival (OS) and response to immune checkpoint inhibitors treatment...

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Source

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Identifiers

PMID: 38822443
DOI: 10.1186/s40246-024-00615-7
PMCID: PMC11143690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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