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Article

Multi-regional sequencing reveals the genetic and immune heterogeneity of non-cancerous tissues in gastric cancer.

The Journal of pathology - 1 Aug 2024

Zhou Yong, Li Shen, Hu Yingqi, Xu Xiao, Cui Jiantao, Li Shuaicheng, Li Ziyu, Ji Jiafu, Xing Rui

Abstract excerpt

Gastric cancer (GC) is one of the most heterogeneous tumors. However, research on normal tissue adjacent to the tumor (NAT) is very limited. We performed multi-regional omics sequencing on 150 samples to assess the genetic basis and immune microenvironment in NAT and matched primary tumor or lymph node metastases. NATs demonstrated different mutated genes compared with GC, and NAT genomes underwent independent...

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PMID: 38845115
DOI: 10.1002/path.6297

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