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Article

Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer.

Oncogene - 1 Jul 2021

Wang Jingyuan, Xiu Joanne, Baca Yasmine, Battaglin Francesca, Arai Hiroyuki, Kawanishi Natsuko, Soni Shivani, Zhang Wu, Millstein Joshua, Salhia Bodour, Goldberg Richard M, Philip Philip A, Seeber Andreas, Hwang Jimmy J, Shields Anthony F, Marshall John L, Astsaturov Igor, Craig Lockhart A, Gatalica Zoran, Michael Korn W, Lenz Heinz-Josef

Abstract excerpt

Frequent mutations of genes in the histone-lysine N-methyltransferase 2 (KMT2) family members were identified in gastric cancers (GCs). Understanding how gene mutations of KMT2 family affect cancer progression and tumor immune microenvironment may provide new treatment strategies. A total of 1245 GCs were analyzed using next-generation sequencing, whole transcriptome sequencing, immunohistochemistry (Caris Life...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34163031
DOI: 10.1038/s41388-021-01840-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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