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PIK3CA somatic mutations as potential biomarker for immunotherapy in elder or TP53 mutated gastric cancer patients.

Clinical genetics - 1 Feb 2023

Yao Jun, You Qing, Zhang Xin, Zhang Yu, Xu Jiapeng, Zhao Xiaokai, Li Jieyi, Wang Xintao, Gong Ziying, Zhang Daoyun, Wang Weijun

Abstract excerpt

Immune checkpoint inhibitors (ICIs) improve overall survival in patients with advanced gastric cancer (GC). However, the molecular characterization of GC in ICIs responders is unclear. A total of 288 advanced GC patients were included in this study. Next-generation sequencing analysis was performed on tumor tissue and paired blood to screen for somatic mutants in 639 tumor-associated genes. We demonstrated that...

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PMID: 36346122
DOI: 10.1111/cge.14260

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