Article
Single cell sequencing of neutrophils demonstrates phenotypic heterogeneity and functional plasticity in health, disease, and cancer.
Chinese clinical oncology - 1 Apr 2023
McLaren Alistair S, Fetit Rana, Wood Colin S, Falconer John, Steele Colin W
Abstract excerpt
A vital constituent of innate immunity, neutrophils had previously been considered functionally rigid with a fixed, defined role in host pathogen response, in part due to their fleeting lifespan. However, that consensus opinion has changed with evidence of functional neutrophil plasticity in a range of diseases including cancer. Typically difficult to sequence due to their low level of transcriptomic activity,...
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