CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

doi:10.1158/2159-8290.CD-23-1092

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CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells.

Cancer discovery - 4 Oct 2024

Waarts Michael R, Mowla Shoron, Boileau Meaghan, Martinez Benitez Anthony R, Sango Junya, Bagish Maya, Fernández-Maestre Inés, Shan Yufan, Eisman Shira E, Park Young C, Wereski Matthew, Csete Isabelle, O'Connor Kavi, Romero-Vega Angelica C, Miles Linde A, Xiao Wenbin, Wu Xiaodi, Koche Richard P, Armstrong Scott A, Shih Alan H, Papapetrou Eirini P, Butler Jason M, Cai Sheng F, Bowman Robert L, Levine Ross L

Abstract excerpt

Clonal hematopoiesis (CH) is a common premalignant state in the blood and confers an increased risk of blood cancers and all-cause mortality. Identification of therapeutic targets in CH has been hindered by the lack of an ex vivo platform amenable for studying primary hematopoietic stem and progenitor cells (HSPCs). Here, we utilize an ex vivo co-culture system of HSPCs with bone marrow endothelial cells to...

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PMID: 38819218
DOI: 10.1158/2159-8290.CD-23-1092
PMCID: PMC11452290

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