Article

Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms

2019-11-26

Abstract excerpt

Myeloproliferative neoplasms (MPNs) cause the over-production of blood cells such as erythrocytes (polycythemia vera) or platelets (essential thrombocytosis). JAK2 V617F is the most prevalent somatic mutation in many MPNs, but previous modeling of this mutation in mice relied on transgenic overexpression and resulted in diverse phenotypes that were in some cases attributed to expression level. CRISPR-Cas9 engineer...

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Literature Corpus work: b1c7a52e-0089-568c-818c-fbc7f4bef76f
DOI: 10.1101/855452

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