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Can Ruxolitinib Crash TET2- and IDH2-Driven Clonal Hematopoiesis?

Cancer discovery - 4 Oct 2024

Khabusheva Elmira, Goodell Margaret A

Abstract excerpt

In this issue, Waarts and colleagues developed an advanced ex vivo CRISPR screening platform to identify vulnerabilities in clonal hematopoiesis (CH). This unique system allowed the authors to identify a link between IDH2 and TET2 CH mutations, histone demethylases, and altered cytokine signaling, which enabled targeting by ruxolitinib leading to the elimination of CH clones, offering a possible path for...

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PMID: 39363743
DOI: 10.1158/2159-8290.CD-24-1020

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