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Efficient silencing of hepatitis B virus S gene through CRISPR‐mediated base editing

26 Mar 2022

Abstract excerpt

Hepatitis B virus (HBV) infection is a major risk factor of liver cirrhosis and hepatocellular carcinoma. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) has been used to precisely edit the HBV genome and eliminate HBV through non-homologous end-joining repair of double-stranded break (DSB). However, the CRISPR/Cas9-mediated DSB triggers instability of host...

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PMID: 35338607
DOI: 10.1002/hep4.1933

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