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Article

Impact of Clonal Hematopoiesis-Associated Mutations in Phase I Patients Treated for Solid Tumors: An Analysis of the STING Trial.

JCO precision oncology - 1 May 2024

Rodriguez Julieta, Baldini Capucine, Bayle Arnaud, Pages Arnaud, Danlos François Xavier, Vasseur Damien, Rouleau Etienne, Lacroix Ludovic, Alonso de Castro Beatriz, Goldschmidt Vincent, Seknazi Lauren, Hollebecque Antoine, Michot Jean-Marie, Champiat Stephane, Marabelle Aurelien, Ouali Kaissa, Marzac Christophe, Ponce Santiago, Micol Jean-Baptiste, Chaput Nathalie, Massard Christophe, Italiano Antoine

Abstract excerpt

PURPOSE: With liquid biopsy's widespread adoption in oncology, an increased number of clonal hematopoiesis-associated mutations (CHm) have been identified in patients with solid tumors. However, its impact on patient outcomes remains unclear. This study aimed to analyze and describe CHm in a cohort of phase I patients. METHODS: Retrospective data collection from medical records and molecular profiles (Foundation...

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Identifiers

PMID: 38815178
DOI: 10.1200/PO.23.00631

Genes

DNMT3A
ASXL1
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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