Article
Liquid biopsy-based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results.
Histopathology - 1 Jun 2024
Mata Douglas A, Lee Jessica K, Shanmugam Vignesh, Marcus Chelsea B, Schrock Alexa B, Williams Erik A, Ritterhouse Lauren L, Hickman Richard A, Janovitz Tyler, Patel Nimesh R, Kroger Benjamin R, Ross Jeffrey S, Mirza Kamran M, Oxnard Geoffrey R, Vergilio Jo-Anne, Elvin Julia A, Benhamida Jamal K, Decker Brennan, Xu Mina L
Abstract excerpt
AIMS: Liquid biopsy (LBx)-based next-generation sequencing (NGS) of circulating tumour DNA (ctDNA) can facilitate molecular profiling of haematopoietic neoplasms (HNs), particularly when tissue-based NGS is infeasible. METHODS AND RESULTS: We studied HN LBx samples tested with FoundationOne Liquid CDx, FoundationOne Liquid, or FoundationACT between July 2016 and March 2022. We identified 271 samples: 89...
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