Article
Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes.
Blood advances - 8 Oct 2024
Nead Kevin T, Kim Taebeom, Joo LiJin, McDowell Tina L, Wong Justin W, Chan Irenaeus C C, Brock Elizabeth, Zhao Jing, Xu Ting, Tang Chad, Lee Chang-Lung, Abe Jun-Ichi, Bolton Kelly L, Liao Zhongxing, Scheet Paul A, Lin Steven H
Abstract excerpt
ABSTRACT: Exposure to cancer therapies is associated with an increased risk of clonal hematopoiesis (CH). The objective of our study was to investigate the genesis and evolution of CH after cancer therapy. In this prospective study, we undertook error-corrected duplex DNA sequencing in blood samples collected before and at 2 time points after chemoradiation in patients with esophageal or lung cancer recruited...
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