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Article

Pan-cancer single-cell landscape of drug-metabolizing enzyme genes

17 May 2024

Abstract excerpt

OBJECTIVE: Varied expression of drug-metabolizing enzymes (DME) genes dictates the intensity and duration of drug response in cancer treatment. This study aimed to investigate the transcriptional profile of DMEs in tumor microenvironment (TME) at single-cell level and their impact on individual responses to anticancer therapy. METHODS: Over 1.3 million cells from 481 normal/tumor samples across 9 solid cancer...

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PMID: 38814173
DOI: 10.1097/fpc.0000000000000538

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