Back to search

Article

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

2021-10-26

Abstract excerpt

Drugs that kill tumors through multiple mechanisms have potential for broad clinical benefits, with a reduced propensity to resistance. We developed BipotentR, a computational approach to find cancer-cell-specific regulators that simultaneously modulate tumor immunity and another oncogenic pathway. Using tumor metabolism as proof-of-principle, BipotentR identified 38 candidate immune-metabolic regulators by combin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b2d8a25f-6602-5b98-805c-e90cf4402ff3
DOI
10.1101/2021.10.25.465724
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor AlphaDOI 10.1101/2021.10.25.465724
Integrated bulk and single-cell transcriptomic analysis reveals a tryptophan metabolism-driven prognostic signature and therapeutic landscape in triple- negative breast cancerSemantic proximity
EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancerSemantic proximity
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancerSemantic proximity
Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancerSemantic proximity
Unveiling ESR1's Network Centrality Through Multi-Omics Fusion and AI: Implications for Next-Generation Endocrine TherapiesSemantic proximity
Real-world clinical multi-omics analyses reveal bifurcation of ER-independent and ER-dependent drug resistance to CDK4/6 inhibitorsSemantic proximity
A Pan-Cancer Atlas of Metabolic Regulatory Circuitries Integrating Multi-Omic, Immune, and Clinical DimensionsSemantic proximity
Metabolic predictors of response to immune checkpoint blockade therapySemantic proximity
Metabolic predictors of response to immune checkpoint blockade therapySemantic proximity
Comprehensive analysis of metabolic reprogramming-related gene signaturesmetabolic reprogramming related gene signature for predicting ovarian cancer prognosis, immune landscape, and potential treatment optionsSemantic proximity
Bioinformatics-based analysis of amino acid metabolism-related features to predict clinical prognosis and immunotherapy response in triple-negative breast cancerSemantic proximity
Phase II proof-of-concept study of durvalumab and cediranib with and without olaparib in recurrent ovarian cancerSemantic proximity
Select a neighboring publication to make it the new centre.