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Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions

25 Jan 2024

Abstract excerpt

Despite considerable efforts to identify human liver cancer genomic alterations that might unveil druggable targets, the systematic translation of multiomics data remains challenging. Here, we report success in long-term culture of 64 patient-derived hepatobiliary tumor organoids (PDHOs) from a Chinese population. A divergent response to 265 metabolism- and epigenetics-related chemicals and 36 anti-cancer drugs...

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PMID: 38278146
DOI: 10.1016/j.xcrm.2023.101375

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